St Mary’s Hospital Redevelopment to Strengthen Paddington Life Sciences Cluster
Work has begun on the first stage of a masterplan to redevelop St Mary’s Hospital in Paddington, a major project that will redevelop one of West London’s key healthcare and life sciences sites. Imperial College Healthcare NHS Trust has appointed Stanhope Plc and Allies and Morrison to lead the masterplanning and planning application for the site, working alongside HOK and a wider design and delivery team.
The proposals include a new state-of-the-art teaching hospital and major trauma centre, alongside the wider regeneration and expansion of the Paddington Life Sciences cluster – a hub of research and innovation. Independent analysis suggests the development could support 12,000–15,000 jobs and up to £15 billion in new economic activity over the next decade.
Paddington Life Sciences is one of the innovation clusters which anchors WestTech London’s ecosystem. The St Mary’s redevelopment will help embed research, education, and clinical breakthroughs, while creating new opportunities for collaboration across healthcare, life sciences, and technology.
The public consultation to help shape the first phase of the masterplan is open until 20 March 2026.
Design work is now underway, with further opportunities for stakeholders to be involved in shaping the masterplan before a planning application is submitted in 2027.
